Tumor Necrosis Factor Induces Pathogenic Mitochondrial Ros In

Tumor necrosis factor induces pathogenic mitochondrial ROS in ....

Jun 24, 2022 . Tumor necrosis factor (TNF) is a critical host resistance factor against tuberculosis. However, excess TNF produces susceptibility by increasing mitochondrial reactive oxygen species (mROS), which initiate a signaling cascade to cause pathogenic necrosis of mycobacterium-infected macrophages. In zeb ....

https://pubmed.ncbi.nlm.nih.gov/35737799/.

Tumor necrosis factor induces pathogenic mitochondrial ROS in ....

Tumor necrosis factor (TNF) mediates resistance to tuberculosis. Excess TNF production, however, is detrimental because it induces pathogenic necrosis of infected macrophages in the tuberculous granuloma, which releases the mycobacteria into the extracellular milieu, promoting their growth and transmission to new hosts..

https://www.science.org/doi/10.1126/science.abh2841.

Tumor necrosis factor induces pathogenic mitochondrial ROS in ....

Welcome to r/science!This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are now allowed as responses to this comment.Any anecdotal comments elsewhere in the ....

https://www.reddit.com/r/science/comments/vlp4o3/tumor_necrosis_factor_induces_pathogenic/.

IMMUNOMETABOLISM Tumor necrosis factor induces ….

Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport Francisco J. Roca1+, Laura J. Whitworth1,2, Hiran A. Prag3, Michael P. Murphy1,3, Lalita Ramakrishnan1,2* Tumor necrosis factor (TNF) is a critical host resistance factor against tuberculosis. However, excess TNF.

https://www.science.org/doi/epdf/10.1126/science.abh2841.

21926 - Gene ResultTnf tumor necrosis factor [ (house mouse)].

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions..

https://www.ncbi.nlm.nih.gov/gene/21926.

7124 - Gene ResultTNF tumor necrosis factor [ (human)].

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell ....

https://www.ncbi.nlm.nih.gov/gene/7124.

24835 - Gene ResultTnf tumor necrosis factor [ (Norway rat)].

Jul 24, 2022 . Gene ID: 24835, updated on 24-Jul-2022. Summary Other designations. tumor necrosis factor, cachectin, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor ligand superfamily member 2. GeneRIFs: Gene References Into Functions. Dopaminergic neuronal death in the substantia nigra associates with change in serum levels of TNF-alpha ....

https://www.ncbi.nlm.nih.gov/gene/24835.

Mouse Tumor necrosis factor α,TNF-α ELISA KIT.

Lactosylceramide-Induced Phosphorylation Signaling to Group IVA Phospholipase A2 via Reactive Oxygen Species in Tumor Necrosis Factor-alpha-Treated Cells. PMID: 28444900 The current study demonstrated that honey can stimulate or suppress the mRNA expression of some pro-inflammatory cytokines in mice brains..

https://www.cusabio.cn/ELISA-Kit/Mouse-Tumor-necrosis-factor-%ce%b1-TNF-%ce%b1-ELISA-KIT-109329.html.

3458 - Gene ResultIFNG interferon gamma [ (human)].

This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an ....

https://www.ncbi.nlm.nih.gov/gene/3458.

7040 - Gene ResultTGFB1 transforming growth factor beta 1.

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated ....

https://www.ncbi.nlm.nih.gov/gene/7040.

MET MET proto-oncogene, receptor tyrosine kinase [ (human)].

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been ....

https://www.ncbi.nlm.nih.gov/gene/4233.

Science:挑战常规!在结核病中,肿瘤坏死因子通过反向电子传 ….

Jun 30, 2022 . ?????????2022?6?24??Science???,?????"Tumor necrosis factor induces pathogenic mitochondrial ROS in ....

https://news.bioon.com/article/67a4e30898f6.html.

1728 - Gene ResultNQO1 NAD(P)H quinone dehydrogenase 1.

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been ....

https://www.ncbi.nlm.nih.gov/gene/1728.

6772 - Gene ResultSTAT1 signal transducer and activator of ....

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated ....

https://www.ncbi.nlm.nih.gov/gene/6772.

CDKN2A cyclin dependent kinase inhibitor 2A [ (human)].

ARF is a tumor suppressor protein that has a pivotal role in the prevention of cancer development through regulating cell proliferation, senescence, and apoptosis. As a factor that induces senescence, the role of ARF as a tumor suppressor is closely linked to the p53-MDM2 axis, which is a key process that restrains tumor formation. Review..

https://www.ncbi.nlm.nih.gov/gene/1029/.

Neutrophil extracellular traps in immunity and disease - Nature.

Oct 09, 2017 . Neutrophil extracellular traps (NETs) protect against infection, but they are also implicated in the pathology associated with various immune-mediated conditions. This Review describes when and ....

https://www.nature.com/articles/nri.2017.105.

12367 - Gene ResultCasp3 caspase 3 [ (house mouse)].

Jul 19, 2022 . results indicate a novel role of Casp-2 in the osteoclast as a modulator of total and mitochondrial ROS and osteoclast differentiation; ... exposure to the EMF of 1950-MHz TD-SCDMA may not promote the tumor formation, but continuous exposure damaged the mitochondria of astrocytes and induce apoptosis through a caspase-3-dependent pathway ....

https://www.ncbi.nlm.nih.gov/gene/12367.

10059 - Gene ResultDNM1L dynamin 1 like [ (human)].

Jul 10, 2022 . This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this ....

https://www.ncbi.nlm.nih.gov/gene/10059.

5925 - Gene ResultRB1 RB transcriptional corepressor 1 [ (human)].

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer ....

https://www.ncbi.nlm.nih.gov/gene/5925.

Browse Articles | Nature.

Jul 27, 2022 . The PI3K-PANK4 axis regulates coenzyme A synthesis, the abundance of acetyl-CoA, and CoA-dependent processes such as lipid metabolism, and these regulatory mechanisms coordinate cellular CoA ....

https://www.nature.com/nature/articles.

5595 - Gene ResultMAPK3 mitogen-activated protein kinase 3.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, ....

https://www.ncbi.nlm.nih.gov/gene/5595.

Hif1a hypoxia inducible factor 1, alpha subunit [ (house mouse)].

Jul 12, 2022 . This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased ....

https://www.ncbi.nlm.nih.gov/gene/15251.

Succinate, an intermediate in metabolism, signal transduction, ROS ....

Aug 01, 2016 . The values of Erev_ANT and Erev_ATPase as a function of ??m and matrix ATP/ADP ratio are depicted in Fig. 2.In Fig. 2, four spaces are discerned; 'A', 'B', 'C' or 'D'.Mitochondria exhibiting such ??m and matrix ATP/ADP ratio pair values that would place them in the 'A' space (green) produce ATP through the synthesizing operation of the F 0 -F 1 ....

https://www.sciencedirect.com/science/article/pii/S0005272816300597.

A platinum nanourchin-based multi-enzymatic platform to disrupt ....

Jul 01, 2022 . Herein, a mesoporous platinum nanourchin (Pt NU)-based multi-enzymatic platform (referred to be as PGMA) was established to disrupt mitochondrial function assisted by modulating the intracellular H 2 O 2 homeostasis [].The PGMA was constructed by covalent conjugation of GOx onto Pt NUs, surface capping with MnCO via hydrophobic interaction and ....

https://www.sciencedirect.com/science/article/pii/S0142961222002125.

Wnt signaling in colorectal cancer: pathogenic role and ….

Jul 14, 2022 . Tumor necrosis factor-?-inducing protein 8-like 2 (TIPE2) is a tumor suppressor for many types of cancer. TIPE2 overexpression increases apoptosis by down-regulating the expression levels of Wnt3a, phospho(p)-?-Catenin and p-glycogen synthase kinase-3? in rectal adenocarcinoma cells. However, the TIPE2 knockdown shows the opposite trend..

https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-022-01616-7.

Toxic Chemicals and Persistent Organic Pollutants ... - ScienceDirect.

Plastics are some of the most well-known non-natural materials that have pervaded the surface of the natural ecosystem. A previous study shows that the production estimated of virgin plastic was 8.3 billion up till 2017 , with the continuous demand, increased production, and poor waste management practices, approximately 12 billion tons of plastic debris would litter the natural ....

https://www.sciencedirect.com/science/article/pii/S2666821122000709.

Dr. Vidyashankar Satyakumar - Head - LinkedIn.

It was observed from the present study that by employing tumor necrosis factor ? (TNF-?) bioassay and reverse transcription-polymerase chain reaction (RT-PCR), Septilin inhibited TNF-? production in LPS (1 ug/mL) stimulated RAW 264.7 cells (p < 0.05). 80% inhibition of TNF-? was observed even at 2.5% Septilin..

https://in.linkedin.com/in/vidyashankar77.

Hepatocellular carcinoma | Nature Reviews Disease Primers.

Jan 21, 2021 . Liver cancer remains a global health challenge, with an estimated incidence of >1 million cases by 2025. Hepatocellular carcinoma (HCC) is the most common form of liver cancer and accounts for ~90 ....

https://www.nature.com/articles/s41572-020-00240-3.

Mechanisms of mitochondrial respiratory adaptation | Nature ….

Jul 08, 2022 . Mitochondrial respiratory function needs to adapt to the energetic demands of the cell. These adaptive responses encompass transcriptional, translational and post-translational mechanisms that ....

https://www.nature.com/articles/s41580-022-00506-6.

Glutathione peroxidase 4–regulated neutrophil ferroptosis induces ....

Aug 12, 2021 . Zhang and colleagues identify a role for cell death by glutathione peroxidase 4 (GPX4)-regulated ferroptosis in neutrophils from patients with systemic lupus erythematosus, which is triggered by ....

https://www.nature.com/articles/s41590-021-00993-3.

The FASEB Journal - Wiley Online Library.

The FASEB Journal publishes high quality and impactful multidisciplinary research covering biology and biomedical sciences at every level of organization: atomic, molecular, cell, tissue, organ, organismic, and population.The journal's scope includes the spectrum of biological and biomedical sciences as well as interdisciplinary research cutting across multiple fields and ....

https://faseb.onlinelibrary.wiley.com/journal/15306860.